A Brief History of Ketamine

Ketamine is a United States Federal Drug Administration approved medication that has been used as an anesthetic since the 1970’s.

Since its discovery in 1962, it has been discovered that in sub-anesthetic doses to be a successful treatment of mood disorders including Depression, PTSD, OCD and Anxiety and Chronic Pain Syndromes including Central Sensitization Syndrome, Fibromyalgia, Reflex Simplex Dystrophy.

According to the World Health Organization on May 27th, 2016: updates on Ketamine were presented, in which new potential medical applications were identified. Potential new therapeutic uses were identified, including for depression and refractory status epilepticus. The use of Ketamine for treating depression is under evaluation in Phase III clinical studies.

The US Federal Drug Administration (FDA) has approved Ketamine for both anesthesia and pain control. However, the FDA has not approved Ketamine Treatment for mood disorders or chronic pain alleviation. Therefore, Ketamine infusions for these indications is considered to be an “off label” usage of the medication. Due to this fact, insurance companies and government insurance programs such as Medicaid and Medicare do not pay for these infusions


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